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Are you a Savella patient?
Are you expecting?

The Savella Pregnancy Registry is an observational registry created to learn about pregnancy outcomes of women who have taken Savella anytime during pregnancy. As there are no studies investigating the effect of Savella in pregnant women, Savella should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

The information gathered in this Registry may supplement other sources of data to assist Health Care Providers and patients in weighing the benefits and risks of being exposed to Savella around the time of conception and during pregnancy.

If you are pregnant and have received Savella you may qualify to participate. The Pregnancy Registry seeks participants who:
  • Have taken Savella anytime during pregnancy.
  • Are pregnant now.
  • Are residents of the United States.
  • Are 18 years old or older.
  • Will allow us to contact your doctor and your baby's doctor for information.

Women willing to enroll may contact the Registry directly by calling

1-877-643-3010

Participation in the Registry will not influence or interfere with the treatment plan recommended by the patient's Health Care Provider. Women should tell their doctor if they become pregnant while taking Savella or if they intend to become pregnant during therapy. Sometimes a woman may become pregnant while taking Savella, or situations may occur during pregnancy for which Savella may be considered important treatment. In all such situations, the decision to stop, start, or continue using Savella should be based on whether the benefit to the mother outweighs any risk to the baby. These decisions should be made with your doctor.

This Registry is sponsored by Forest Research Institute and is managed by INC Research LLC. If you are interested in additional information, click on contact us for the Registry Coordinating Center.

The success of the Registry depends on the continued participation of Health Care Providers and pregnant women who have been exposed to Savella. Participation from patients and Health Care Providers is greatly appreciated.


Thank you in advance for your time and participation. We welcome any questions you may have regarding the Savella Pregnancy Registry.


Savella (milnacipran HCl) is indicated for the management of fibromyalgia in adults. Savella is available by prescription only.
Important Risk Information About Savella
Savella is a selective serotonin and norepinephrine reuptake inhibitor (SNRI), similar to some drugs used for the treatment of depression and other psychiatric disorders. Patients on antidepressants and their families or caregivers should watch for new or worsening symptoms, unusual changes in behavior, thoughts of suicide, anxiety, agitation, panic attacks, difficulty sleeping, irritability, hostility, aggressiveness, impulsivity, restlessness, or extreme hyperactivity. Call your Health Care Provider right away if you have thoughts of suicide or if any of these symptoms are severe or occur suddenly. Be especially observant within the first few months of treatment or whenever there is a change in dose, either increase or decrease. Savella is not approved for use in treating depression.


Questions about Savella

Who should NOT take Savella?
Do not take Savella if you:
  • Are taking or have recently taken a type of drug called a monoamine oxidase inhibitor (MAOI), such as Nardil® (phenelzine sulfate) or Parnate® (tranylcyprominesulfate).
  • Have uncontrolled narrow-angle glaucoma (an eye disease).
    •

    What should I tell my Health Care Provider before taking Savella?
    Before starting Savella, tell your Health Care Provider about all of your medical conditions, including if you have:
  • Hypertension (high blood pressure), tachyarrhythmia (fast heart rate), or other cardiac diseases
  • Liver problems or a history of substantial alcohol use
  • Kidney problems, including dysuria (painful urination)
  • History of mania or seizure disorders
  • Bleeding disorders
  • Glaucoma

    • Also, to avoid a potentially serious or life-threatening condition, tell your Health Care Provider if you are taking, or planning to take, any prescription or over-the-counter medications, including:
  • Other SNRIs, (serotonin reuptake inhibitors), certain migraine or headache medications (triptans), or tryptophan
  • Medication prescribed for a psychiatric or neurological condition
  • NSAID pain relievers (such as ibuprofen or naproxen), aspirin, warfarin, or other blood thinners
  • Diuretics

    • Tell your Health Care Provider if you are pregnant, planning to become pregnant during therapy, or are breastfeeding.

    What should I tell my Health Care Provider before taking Savella?
    Your blood pressure and pulse should be monitored at regular intervals when receiving treatment with Savella.

    You should not operate machinery or drive until you are reasonably certain that Savella treatment does not affect your ability to engage in such activities. Avoid drinking alcohol while taking Savella.

    Call your doctor if you have very high fever, rigid muscles, shaking, confusion, or rapid changes in heart rate and/or blood pressure. These may be signs of a rare but serious side effect.

    Talk with your Health Care Provider before stopping Savella or changing your dose. Withdrawal symptoms can occur, particularly when discontinuation is abrupt.

    What should I tell my Health Care Provider before taking Savella?
    The most common side effect associated with Savella treatment is nausea. In clinical trials, patients experiencing nausea described it as mild to moderate. Other common side effects were headache, constipation, dizziness, insomnia, hot flashes, hyperhidrosis (excessive sweating), vomiting, palpitations, increased heart rate, dry mouth, and hypertension.

    This is not a complete list of side effects.